A BAC‐array platform for comparative genomic hybridization was constructed from a library
of 32,433 clones providing complete genome coverage, and evaluated by screening for …

Chromosome analysis is an important component to the diagnosis of congenital anomalies,
developmental delay, and mental retardation. Routine chromosome analysis identifies …

Aberrant methylation of CpG islands and genomic deletion are two predominant
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …

Small, submicroscopic, genomic deletions and duplications (1 kb to 10 Mb) constitute up to
15% of all mutations underlying human monogenic diseases. Novel genomic technologies …

Gains in the long arm of chromosome 8 (8q) are believed to be associated with poor
outcome and the development of hormone-refractory prostate cancer. Based on a meta …

To identify recurrent genomic changes in mantle cell lymphoma (MCL), we used high-
resolution comparative genomic hybridization (CGH) to bacterial artificial chromosome …

The field of cytogenetics has focused on studying the number, structure, function and origin
of chromosomal abnormalities and the evolution of chromosomes. The development of …

The identification of cytogenetic imbalance is an important component of clinical genetics.
About 1 in 154 newborns has a chromosome abnormality. Conventional cytogenetic …

US10229244B2 - Methods for identifying DNA copy number changes using hidden markov
model based estimations - Google Patents US10229244B2 - Methods for identifying DNA copy …

Telomeric chromosome rearrangements may cause mental retardation, congenital
anomalies, and miscarriages. Automated detection of subtle deletions or duplications …