Background It is apparent that genomes harbor much structural variation that is largely
undetected for technical reasons. Such variation can cause artifacts when short-read …

Oncogene-induced replication stress (RS) promotes cancer development but also impedes
tumor growth by activating anti-cancer barriers. To determine how cancer cells adapt to RS …

Given that gene duplication is a major driving force of evolutionary change and the key
mechanism underlying the emergence of new genes and biological processes, this study …

Alterations in the genome that lead to changes in DNA sequence copy number are a
characteristic of solid tumors and are found in association with developmental abnormalities …

The development of solid tumors is associated with acquisition of complex genetic
alterations, indicating that failures in the mechanisms that maintain the integrity of the …

Structural genetic alterations in cancer often involve gene loss or gene amplification. With
the advent of microarray approaches for the analysis of the genome, as exemplified by array …

Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded
complex regions of the genome that are rich in duplications and prone to rearrangement. In …

Oncogene-expressing human papillomavirus type 16 (HPV16) is found in a subset of head
and neck squamous cell carcinomas (HNSCC). HPV16 drives carcinogenesis by …

Array-based comparative genomic hybridization (CGH) measures copy-number variations at
multiple loci simultaneously, providing an important tool for studying cancer and …

Genomes of solid tumors are characterized by gains and losses of regions, which may
contribute to tumorigenesis by altering gene expression. Often the aberrations are extensive …