Canine transmissible venereal tumor (CTVT) is an infectious disease of dogs. Remarkably,
the infectious agent is the cancerous cell itself. To investigate its origin and spread, we …

Array-based comparative genomic hybridization (array-CGH) provides a high-throughput,
high-resolution method to measure relative changes in DNA copy number simultaneously at …

Molecular mechanisms of leukemogenesis have been successfully unraveled by studying
genes involved in simple rearrangements including balanced translocations and inversions …

DNA Copy number variation (CNV) has recently gained considerable interest as a source of
genetic variation that likely influences phenotypic differences. Many statistical and …

Structural changes (deletions, insertions, and inversions) between human and chimpanzee
genomes have likely had a significant impact on lineage-specific evolution because of their …

Background: Malformations are a major cause of morbidity and mortality in full term infants
and genomic imbalances are a significant component of their aetiology. However, the …

Array-based comparative genomic hybridization (CGH) allows for the simultaneous
examination of thousands of genomic loci at 1–2 Mb resolution. Copy number alterations …

Cancer progresses through a series of histopathological stages. Progression is thought to
be driven by the accumulation of genetic alterations and consequently gene expression …

Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is
only recently that there has been hope for the possibility to understand its pathogenesis and …

Abstract Hidden Markov models (HMMs) and related models have become standard in
statistics during the last 15--20 years, with applications in diverse areas like speech and …