Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …

Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …

Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung,
urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Depression is a mental disorder associated with environmental, genetic and psychological
factors. Recent studies indicate that chronic neuro-inflammation may affect brain physiology …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …