Pharmacology and structure of P2Y receptors
I von Kügelgen, K Hoffmann - Neuropharmacology, 2016 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
[HTML][HTML] Inherent P2X7 receptors regulate macrophage functions during inflammatory diseases
W Ren, P Rubini, Y Tang, T Engel, P Illes - International Journal of …, 2021 - mdpi.com
Macrophages are mononuclear phagocytes which derive either from blood-borne
monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver …
monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver …
[HTML][HTML] Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration
C Ledderose, K Liu, Y Kondo… - The Journal of …, 2018 - Am Soc Clin Investig
T cells must migrate in order to encounter antigen-presenting cells (APCs) and to execute
their varied functions in immune defense and inflammation. ATP release and autocrine …
their varied functions in immune defense and inflammation. ATP release and autocrine …
Molecular pharmacology of P2Y receptor subtypes
I von Kuegelgen - Biochemical Pharmacology, 2021 - Elsevier
Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
[HTML][HTML] High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity
GB da Silva, D Manica, AP da Silva… - Journal of Molecular …, 2022 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
significantly impacted the world and has driven many researchers into the pathophysiology …
significantly impacted the world and has driven many researchers into the pathophysiology …
The purinergic system as a pharmacological target for the treatment of immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …
Imaging adenosine triphosphate (ATP)
M Rajendran, E Dane, J Conley… - The Biological …, 2016 - journals.uchicago.edu
Adenosine triphosphate (ATP) is a universal mediator of metabolism and signaling across
unicellular and multicellular species. There is a fundamental interdependence between the …
unicellular and multicellular species. There is a fundamental interdependence between the …
Purinergic signalling in brain ischemia
Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …
After ischemia a primary damage due to the early massive increase of extracellular …
Regulation of the T cell response by CD39
MC Takenaka, S Robson, FJ Quintana - Trends in immunology, 2016 - cell.com
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the
phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions …
phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions …
[HTML][HTML] Hyperhomocysteinemia and cardiovascular disease: is the adenosinergic system the missing link?
F Paganelli, G Mottola, J Fromonot, M Marlinge… - International journal of …, 2021 - mdpi.com
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …