T cells must migrate to encounter antigen-presenting cells and perform their roles in host
defense. Here, we found that autocrine stimulation of the purinergic receptor P2Y11 …

The involvement of purinergic signalling in the physiology of erythrocytes, platelets and
leukocytes was recognised early. The release of ATP and the expression of purinoceptors …

The distal lung provides an intricate structure for gas exchange in mammalian lungs.
Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the …

Extracellular purinergic products, particularly ATP, have recently been implicated to regulate
immune cell functions and contribute to aberrant inflammatory responses of immune …

Mast cells are responsible for the majority of allergic conditions. It was originally thought that
almost all allergic events were mediated directly only via the high-affinity immunoglobulin E …

Abstract P2Y receptors are G protein-coupled receptors whose physiological agonists are
the nucleotides ATP, ADP, UTP, UDP and UDP-glucose. Eight P2Y receptors have been …

Mast cell–airway smooth muscle (ASM) interactions play a major role in the immunoglobulin
(Ig) E-dependent bronchoconstriction seen in asthma but less is known about IgE …

The ectoenzymes CD39 and CD73 degrade extracellular ATP to adenosine. ATP is
released by stressed or damaged cells and provides pro-inflammatory signals to immune …

Since purinergic signaling was discovered in the early 1970s, it has been shown that
extracellular nucleotides, and their derivative nucleosides, are released in a regulated or …

Cell death is a basic physiological process that occurs in all living organisms. A few key
players in these mechanisms, as well as various forms of cell death programming, have …