Antigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes
in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP …

The inflammatory response is a major factor in stroke pathophysiology and contributes to
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …

Human ecto-5′-nucleotidase (h-ecto-5′-NT, CD73) is a homodimeric Zn2+-binding
metallophosphoesterase that hydrolyzes adenosine 5′-monophosphate (5′-AMP) to …

Platelet activation is the first response to tissue damage and, if unrestrained, may promote
chronic inflammation-related cancer, mainly through the release of soluble factors and …

In autoimmune patients, regulatory T cells (Tregs) are increasingly found to be unable to
suppress patient-derived T cells, an outcome referred to as Treg resistance. In this study, we …

Platelets are necessary for maintaining haemostasis. Separately, platelets are important for
the propagation of inflammation during the host immune response against infection. The …

Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend
their functions beyond the cell. In this context, purinergic signaling plays a crucial role in …

Highlights•Sepsis is an organ dysfunction caused by a deregulated immune response to an
infection.•At present, no approved treatment options exist that can improve sepsis …

Understanding the rationale for the generation of a pool of highly differentiated effector
memory CD8+ T cells displaying a weakened capacity to scrutinize for peptides complexed …

Mast cells (MCs) play a critical role in allergic inflammation. Although purinergic signalling is
implicated in the regulation of various immune responses, its role in MC function is not fully …