Real-time microfluidic blood-counting system for PET and SPECT preclinical pharmacokinetic studies
Small-animal nuclear imaging modalities have become essential tools in the development
process of new drugs, diagnostic procedures, and therapies. Quantification of metabolic or …
process of new drugs, diagnostic procedures, and therapies. Quantification of metabolic or …
An analysis of whole body tracer kinetics in dynamic PET studies with application to image-based blood input function extraction
J Huang, F O'Sullivan - IEEE transactions on medical imaging, 2014 - ieeexplore.ieee.org
In a positron emission tomography (PET) study, the local uptake of the tracer is dependent
on vascular delivery and retention. For dynamic studies the measured uptake time-course …
on vascular delivery and retention. For dynamic studies the measured uptake time-course …
Kinetic Modeling of Brain [18-F]FDG Positron Emission Tomography Time Activity Curves with Input Function Recovery (IR) Method
Accurate positron emission tomography (PET) data quantification relies on high-quality input
plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing …
plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing …
[11C]-Acetoacetate PET imaging: a potential early marker for cardiac heart failure
E Croteau, S Tremblay, S Gascon… - Nuclear Medicine and …, 2014 - Elsevier
The ketone body acetoacetate could be used as an alternate nutrient for the heart, and it
also has the potential to improve cardiac function in an ischemic–reperfusion model or …
also has the potential to improve cardiac function in an ischemic–reperfusion model or …
Short 2-[18F]Fluoro-2-Deoxy-D-Glucose PET Dynamic Acquisition Protocol to Evaluate the Influx Rate Constant by Regional Patlak Graphical Analysis in Patients …
L Indovina, V Scolozzi, A Capotosti, S Sestini… - Frontiers in …, 2021 - frontiersin.org
Purpose: To test a short 2-[18F] Fluoro-2-deoxy-D-glucose (2-[18F] FDG) PET dynamic
acquisition protocol to calculate Ki using regional Patlak graphical analysis in patients with …
acquisition protocol to calculate Ki using regional Patlak graphical analysis in patients with …
Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [11C](R)-Rolipram
CH Lyoo, P Zanotti-Fregonara, SS Zoghbi, JS Liow… - PloS one, 2014 - journals.plos.org
Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-
IDIF) can be reliably used in [11C](R)-rolipram positron emission tomography (PET) scans …
IDIF) can be reliably used in [11C](R)-rolipram positron emission tomography (PET) scans …
Image Derived Input Function for [18F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain
In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling
system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) …
system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) …
A Comparison of Arterial Input Function Interpolation Methods for Patlak Plot Analysis of 68Ga-PSMA-11 PET Prostate Cancer Studies
NJ Smith, DT Newton, D Gunderman… - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
Positron emission tomography (PET) imaging enables quantitative assessment of tissue
physiology. Dynamic pharmacokinetic analysis of PET images requires accurate estimation …
physiology. Dynamic pharmacokinetic analysis of PET images requires accurate estimation …
Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts
P Zanotti-Fregonara, JS Liow, C Comtat… - Nuclear medicine …, 2012 - journals.lww.com
Background Image-derived input function (IDIF) from carotid arteries is an elegant
alternative to full arterial blood sampling for brain PET studies. However, a recent study …
alternative to full arterial blood sampling for brain PET studies. However, a recent study …
Evaluation of Non-Invasive Methods for (R)-[11C]PK11195 PET Image Quantification in Multiple Sclerosis
DBA Mantovani, MS Pitombeira, PN Schuck… - Journal of …, 2024 - mdpi.com
This study aims to evaluate non-invasive PET quantification methods for (R)-[11C] PK11195
uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in …
uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in …