Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

This review summarises the evidence that chronic low grade inflammation triggers changes
that contribute to the mental and physical ill health of patients with major depression …

Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of
homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

The mammalian brain is supplied with blood by specialized vasculature that is structurally
and functionally distinct from that of the periphery. A defining feature of this vasculature is a …

We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

Intraventricular hemorrhage (IVH) is a major complication of prematurity. IVH typically
initiates in the germinal matrix, which is a richly vascularized collection of neuronal-glial …