Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

The structural and functional integrity of the brain depends on the delicate balance between
substrate delivery through blood flow and energy demands imposed by neural activity …

The brain is critically dependent on a continuous supply of blood to function. Therefore, the
cerebral vasculature is endowed with neurovascular control mechanisms that assure that …

The cellular mechanisms underlying functional hyperemia—the coupling of neuronal
activation to cerebral blood vessel responses—are not yet known. Here we show in rat …

The brain is a heterogeneous organ with regionally varied and constantly changing
energetic needs. Blood vessels in the brain are equipped with control mechanisms that …

Local increase in blood flow during neural activity forms the basis for functional brain
imaging, but its mechanism remains poorly defined. Here we show that cortical astrocytes in …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in
space and time that modern imaging methods use local hemodynamics as a measure of …

The haemodynamic responses to neural activity that underlie the blood-oxygen-level-
dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI) of the brain …

Cyclooxygenase (COX) catalyses the first committed step in the synthesis of prostanoids, a
large family of arachidonic acid metabolites comprising prostaglandins, prostacyclin, and …