One of the major obstacles to successful paclitaxel (PTX) chemotherapy is toxic side effects,
which are often due to the conventional surfactants used, such as Cremophor EL. PTX is …

Previously, we developed a solid lipid nanoparticle (SLN) formulation of 4-(N)-
docosahexaenoyl 2′, 2′-difluorodeoxycytidine (DHA-dFdC), a compound with promising …

Background/Aim: Polymeric micelles are promising vehicles for paclitaxel delivery. Further
improvement in the stability of the micelle formulation is desirable. Materials and Methods …

Objective of the present study is to prepare a co crystal of paclitaxel with improved solubility
and bio availability. Paclitaxel is poorly water soluble and low bioavailable drug, this low …

Peroral administration of drug-loaded PLGA nanoparticles (NPs) is gaining utmost attention
in recent years. PLGA NPs have been successfully employed for peroral delivery of varied …

紫杉醇具有独特的微管稳定作用而被广泛用于多种实体瘤的治疗, 在多个国家被批准作为癌症术
后化疗药物. 纳米给药系统能够较好地解决紫杉醇现有剂型水溶性差和辅助溶剂聚氧乙烯蓖麻油 …

Tocophersolan (D-α-tocopheryl polyethylene glycol succinate or TPGS) is a non-ionic
surfactant fabricated by esterifying Vitamin E succinate with polyethylene glycol. Owing to its …

The aim of this study was to evaluate the underlying mechanism of enhanced oral
absorption of paclitaxel (PTX)-loaded chitosan–vitamin E succinate–N-acetyl-l-cysteine (CS …

Objective: The low oral bioavailability of paclitaxel (PAC) because of its limited aqueous
solubility and poor intestinal permeability after being administered orally suggests the need …

Paclitaxel (PCT) is a cytotoxic agent with a broad antineoplastic activity. IV formulation of
PCT causes hypersensitivity reactions in some patients and oral administration is an …