Highlights•USP7, a widely studied deubiquitinating enzyme, spares substrates from
proteasome degradation.•USP7 interacts with many proteins whose alterations promote …

Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading
microorganisms through autophagic machinery. The intracellular bacterial pathogen …

Chemoproteomics has made significant progress in investigating small-molecule-protein
interactions. However, the proteome-wide profiling of cysteine ligandability remains …

Highlights•Drug resistance towards chemotherapy and molecularly targeted therapies
remains a great challenge in cancer treatments.•Deubiquitinating enzymes (DUBs) regulate …

Metastatic progression is the main cause of mortality in breast cancer, necessitating the
determination of the molecular events driving this process for the development of new …

The mesenchymal (MES) subtype of glioblastoma (GBM) is a highly aggressive, malignant
and proliferative cancer that is resistant to chemotherapy. Runt-related transcription factor 1 …

Apoptosis‐inducing factor (AIF) plays a dual role in regulating cell survival and apoptosis,
acting as a prosurvival factor in mitochondria via its NADH oxidoreductase activity and …

The ubiquitin system is important for drug discovery, and the discovery of selective small-
molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely …

MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from
other family members based on its relatively short half-life. Emerging studies have revealed …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …