Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Intratumoral hypoxia (reduced O 2 availability) is a common finding in human cancer and
leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the expression …

INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …

The refractory diabetic wound has remained a worldwide challenge as one of the major
health problems. The impaired angiogenesis phase during diabetic wound healing partly …

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

Hypoxia occurs frequently in human cancers and induces adaptive changes in cell
metabolism that include a switch from oxidative phosphorylation to glycolysis, increased …

An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …

Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …

Abstract The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial
tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and …