[HTML][HTML] Clinical Implications of Kratom (Mitragyna speciosa) Use: a Literature Review

E Prevete, KPC Kuypers, EL Theunissen… - Current Addiction …, 2023 - Springer
Abstract Purpose of Review This work aims to provide an up-to-date review of the preclinical
and clinical scientific literature on the therapeutic value of kratom to better understand the …

[HTML][HTML] Kratom abuse potential 2021: an updated eight factor analysis

JE Henningfield, DW Wang, MA Huestis - Frontiers in Pharmacology, 2022 - frontiersin.org
Drugs are regulated in the United States (US) by the Controlled Substances Act (CSA) if
assessment of their abuse potential, including public health risks, show such control is …

Kratom use as more than a “self-treatment”

KE Smith, KE Dunn, JM Rogers… - The American Journal …, 2022 - Taylor & Francis
Background: Mitragyna speciosa (kratom) is increasingly used in the United States for its
pharmacological effects. Kratom's relative novelty makes for a dynamic situation, such that …

Clinical assessment of the drug interaction potential of the psychotropic natural product kratom

RS Tanna, JT Nguyen, DL Hadi… - Clinical …, 2023 - Wiley Online Library
Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are
increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain …

Diagnostic ambiguities and underuse of clinical assessment tools: A systematic review of case reports on kratom addiction and physical dependence

KE Smith, JD Feldman, D Schriefer, ST Weiss… - Current Addiction …, 2023 - Springer
Abstract Purpose of Review This systematic review examines case reports of kratom
physical dependence or addiction, focusing on assessment, diagnosis, and treatment …

[HTML][HTML] Inhibition of α-Glucosidase and Pancreatic Lipase Properties of Mitragyna speciosa (Korth.) Havil. (Kratom) Leaves

T Limcharoen, P Pouyfung, N Ngamdokmai… - Nutrients, 2022 - mdpi.com
Kratom (Mitragyna speciosa (Korth.) Havil.) has been used to reduce blood sugar and lipid
profiles in traditional medicine, and mitragynine is a major constituent in kratom leaves …

Directed biosynthesis of mitragynine stereoisomers

C Schotte, Y Jiang, D Grzech, TTT Dang… - Journal of the …, 2023 - ACS Publications
Mitragyna speciosa (“kratom”) is used as a natural remedy for pain and management of
opioid dependence. The pharmacological properties of kratom have been linked to a …

Need for clarity and context in case reports on kratom use, assessment, and intervention

KE Smith, KE Dunn, DH Epstein… - Substance …, 2022 - journals.sagepub.com
This Letter to the Editor is a response to Broyan and colleagues who recently published a
Case Report presenting data on 28 patients in the United States who identified kratom as …

[HTML][HTML] Kratom's emergence and persistence within the US polydrug epidemic

KE Smith, JM Rogers, JD Feldman - Current addiction reports, 2023 - Springer
Abstract Purpose of Review Use of “kratom” products, derived from the bioactive botanical
Mitragyna speciosa have increased amidst US polydrug use epidemics. Kratom alkaloids …

Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain

DJ Farkas, S Inan, LN Heydari, CT Johnson, P Zhao… - Life Sciences, 2023 - Elsevier
Aims Mitragynine (MG) is an alkaloid found in Mitragyna speciosa (kratom), a plant used to
self-treat symptoms of opioid withdrawal and pain. Kratom products are commonly used in …