Biomarkers of acute and chronic kidney disease

WR Zhang, CR Parikh - Annual review of physiology, 2019 - annualreviews.org
The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

Rodent models to study sodium retention in experimental nephrotic syndrome

M Xiao, BN Bohnert, F Grahammer… - Acta Physiologica, 2022 - Wiley Online Library
Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different
experimental rodent models have been established for simulating NS, however, not all of …

Single-cell profiling reveals transcriptional signatures and cell-cell crosstalk in anti-PLA2R positive idiopathic membranous nephropathy patients

J Xu, C Shen, W Lin, T Meng, JD Ooi… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

Cytokines network in primary membranous nephropathy

Q Zhao, H Dai, Y Hu, H Jiang, Z Feng, W Liu… - International …, 2022 - Elsevier
There have been extensive studies on the immunological mechanism of primary
membranous nephropathy (PMN). Autoantibodies, being the end product of humoral auto …

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment

EYM Chung, YM Wang, K Keung, M Hu… - Frontiers in …, 2022 - frontiersin.org
Primary membranous nephropathy (PMN) is one of the common causes of adult-onset
nephrotic syndrome and is characterized by autoantibodies against podocyte antigens …

Evaluation of the mechanism of Danggui-Shaoyao-San in regulating the metabolome of nephrotic syndrome based on urinary metabonomics and bioinformatics …

Y Wang, S Fan, MO Yang, G Shi, S Hu, D Yin… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Danggui-Shaoyao-San (DSS), a well-known
classic Traditional Chinese medicine (TCM) formula for enhancing Qi (vital energy and …

Recent advances in molecular mechanisms of the NKG2D pathway in hepatocellular carcinoma

J Wang, CD Li, L Sun - Biomolecules, 2020 - mdpi.com
Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant
proliferation, invasion, and metastasis are closely related to the cellular immune function of …

Mechanism of action of Tripterygium wilfordii for treatment of idiopathic membranous nephropathy based on network pharmacology

H Shi, Y Hou, X Su, J Qiao, Q Wang, X Guo, Z Gao… - Renal …, 2022 - Taylor & Francis
Background Although thunder god vine (Tripterygium wilfordii) has been widely used for
treatment of idiopathic membranous nephropathy (IMN), the pharmacological mechanisms …

Peripheral blood lymphocyte subsets in children with nephrotic syndrome: a retrospective analysis

Y Deng, Y Ou, CJ Mo, L Huang, X Qin, S Li - BMC nephrology, 2023 - Springer
Background Nephrotic syndrome (NS) in children is widely believed to be associated with
severe changes in the immune system. Based on lymphocyte subset analysis, we examined …

The Role of TNF-α in the Pathogenesis of Idiopathic Nephrotic Syndrome and Its Usefulness as a Marker of the Disease Course

A Pukajło-Marczyk, D Zwolińska - Journal of Clinical Medicine, 2024 - mdpi.com
Background: The pathogenesis of idiopathic nephrotic syndrome (INS) has not been fully
explained. Among the likely factors, tumor necrosis factor-alpha (TNF-α) is considered. We …