Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP) and
disability in the elderly, imposing significant public health and economic burden worldwide …

Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular
intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of …

Background Degenerative disc disease, a major cause of low back pain and associated
neurological symptoms, is a global health problem with the high morbidity, workforce loss …

Ferroptosis is a novel type of cell death associated with iron accumulation and excessive
lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is …

Epigenetic changes are important considerations for degenerative diseases. DNA
methylation regulates crucial genes by epigenetic mechanism, impacting cell function and …

The incidence of lumbar disc herniation has gradually increased in recent years, and most
patients have symptoms of low back pain and nerve compression, which brings a heavy …

Intervertebral disc degeneration (IVDD) has been considered a major cause of low back
pain. Therefore, further molecular subtypes of IVDD and identification of potential critical …

Regulated cell death (RCD) is a fundamental biological process that plays critical roles in
regulating organogenesis and maintaining homeostasis under physiological conditions, and …

Intervertebral disc degeneration (IDD) is one of the primary causes of low back pain (LBP),
which seriously affects patients' quality of life. In recent years, interleukin (IL)-17 has been …

Background Hereditary hemochromatosis (HH) is a common autosomal recessive disorder.
This disease affects gut iron transport, leading to iron overload, which affects immune …