Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

Antiretroviral therapy, where available, has transformed HIV-1 disease into a treatable and
somewhat chronic infection. This article summarizes the accomplishments thus far and what …

The HIV reverse transcriptase and protease sequence database is an on-line relational
database that catalogues evolutionary and drug-related sequence variation in the human …

Background & Aims: Telaprevir (VX-950), a hepatitis C virus (HCV) NS3· 4A protease
inhibitor, has shown strong antiviral activity in phase 1 clinical studies. Because of high …

This study compared the rate of isolation of herpes simplex virus (HSV) from> 36,000
samples of mucosal secretions obtained from 296 HSV-infected persons versus the rate of …

Although caused by vastly different pathogens, the world's three most serious infectious
diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug …

The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to
global tuberculosis (TB) control. Although culture-based methods have been regarded as …

Two important databases are often used in HIV genetic research, the HIV Sequence
Database in Los Alamos, which collects all sequences and focuses on annotation and data …

Background: GS-9137 is a potent low-nanomolar strand transfer inhibitor of HIV-1 integrase.
Methods: The antiviral activity, tolerability, pharmacokinetics, and pharmacodynamics of GS …

A substantial number of studies have been performed across the world to determine
transmitted drug resistance. Large variations between different parts of the world can be …