CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

LAG-3 (Lymphocyte activation gene 3) protein is a checkpoint receptor that interacts with
LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN …

Lower-grade glioma (LGG) is the common malignant primary tumor in the central nervous
system, which most patients will eventually develop into highly aggressive gliomas despite …

The aging microenvironment serves important roles in cancers. However, most studies focus
on circumscribed hot spots such as immunity and metabolism. Thus, it is well ignored that …

Background As an important part of tumor immunotherapy for adjunct, therapeutic tumor
vaccines have been effective against multiple solid cancers, while their efficacy against …

Background: Clinical benefits from standard therapies against glioblastoma (GBM) are
limited in part due to the intrinsic radio-and chemo-resistance. As an essential part of tumor …

Simple Summary Thyroid cancer is the most common solid tumor of the endocrine glands.
The cancer cell contribution to thyroid cancer development and progression has been …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid and
easily develops into distant metastasis. PD-L1 is known to be associated with the …

Simple Summary The composite network of stromal, immune, vascular and cancer cells,
which constitutes the tumor microenvironment (TME), has emerged as a player in thyroid …