The inflammatory responses in sepsis and hemorrhage remain a major cause of death.
Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its …

Inflammatory responses, characterized by the overproduction of numerous proinflammatory
mediators by immune cells, is essential to protect the host against invading pathogens …

The α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR) is an essential
component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates …

Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

BACKGROUND/AIMS: The role of high mobility group box chromosomal protein 1 in
hepatocellular carcinoma is unknown. The aim of study was to evaluate contributions of high …

High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed,
abundant, nonhistone DNA-binding protein. It has well-established functions in the …

Introduction 3. The role of HMGB1 in the brain 4. TLR4 as a key receptor for HMGB1 in the
brain 5. HMGB1/TLR4 signaling pathways 6. Role of HMGB1 in cerebral ischemia 7. Role of …

Severe sepsis is the leading cause of mortality in intensive care units. The limited ability of
current therapies to reduce sepsis mortality rates has fueled research efforts for the …

Advances in intensive care and antibiotics have prevented the spread of some infections,
though sepsis mortality rates remain high. With failure of over thirty clinical trials, sepsis …

High mobility group box (HMGB)-1 plays an important role in sepsis-associated death in
experimental studies. Heme oxygenase-1 (HO-1) inducers were reported to reduce HMGB1 …