cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment

H Zhang, Y Liu, J Liu, J Chen, J Wang, H Hua… - Journal of Hematology & …, 2024 - Springer
Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Sex related differences in the complex relationship between coffee, caffeine and atrial fibrillation

F Coppi, V Bucciarelli, G Sinigaglia, G Zanini, V Selleri… - Nutrients, 2023 - mdpi.com
This literature review aims to explore the data of articles published on the association
between coffee, caffeine and atrial fibrillation and to analyze any differences between the …

AI-based identification of therapeutic agents targeting GPCRs: introducing ligand type classifiers and systems biology

J Goßen, RP Ribeiro, D Bier, B Neumaier… - Chemical …, 2023 - pubs.rsc.org
Identifying ligands targeting G protein coupled receptors (GPCRs) with novel chemotypes
other than the physiological ligands is a challenge for in silico screening campaigns. Here …

Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects

C Gao, MY Koko, W Hong, J Gankhuyag… - Journal of Agricultural …, 2023 - ACS Publications
The intestinal barrier is critical for maintaining intestinal homeostasis, and its dysfunction is
associated with various diseases. Recent findings have revealed the multifunctional role of …

Adenosinergic System and Neuroendocrine Syncope: What Is the Link?

R Guieu, J Fromonot, G Mottola, B Maille, M Marlinge… - Cells, 2023 - mdpi.com
Although very common, the precise mechanisms that explain the symptomatology of
neuroendocrine syncope (NES) remain poorly understood. This disease, which can be very …

The Role of Adenosine and Its Degradation Enzymes–Adenosinedeaminase and Adenosinekinase in Pathogenesis of Vasovagal Syncope

Z Lazurova, P Mitro, M Popovnakova - European Journal of Internal …, 2022 - Elsevier
Introduction Adenosine is mediator regulating physiological and pathological processes in
organism. It probably plays a role in pathogenesis of vasovagal syncopes (VVS), too …

AI-based novel-chemotype GPCRs drugs: introducing ligand type classifiers and systems biology

J Goßen, RP Ribeiro, D Bier, B Neumaier, P Carloni… - bioRxiv, 2023 - biorxiv.org
Identifying the correct chemotype of ligands targeting receptors (ie, agonist or antagonist) is
a challenge for in silico screening campaigns. Here we present an approach that identifies …

СУЧАСНІ ДОСЯГНЕННЯ В РОЗУМІННІ ПАТОФІЗІОЛОГІЧНИХ МЕХАНІЗМІВ РОЗВИТКУ СИНКОПЕ В ДІТЕЙ

ТА Ковальчук - Актуальні питання педіатрії, акушерства та … - ojs.tdmu.edu.ua
Результати дослідження та їх обговорення. Хоча причини гемодинамічних відмінностей
між пацієнтами з синкопе та загальною популяцією наразі залишаються невідомими …