Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Cell death, particularly that of tubule epithelial cells, contributes critically to the
pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years …

Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently,
there are no targeted therapeutics for preventing and treating AKI. Macrophages, important …

Fibrosis is a common process of tissue repair response to multiple injuries in all chronic
progressive diseases, which features with excessive deposition of extracellular matrix …

Increased expression of AP-1 transcription factor components has been reported in acute
kidney injury (AKI). However, the role of specific components, such as Fosl1, in tubular cells …

Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical
data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein …

Renal interstitial fibrosis (RIF) is a common pathological feature contributing to chronic injury
and maladaptive repair following acute kidney injury. Currently, there is no effective therapy …

Sepsis-induced acute kidney injury (SAKI) is common in critically ill patients and often leads
to poor prognosis. At present, the pathogenesis of SAKI has not been fully clarified, and …

Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting protein
kinase (RIPK) family with serine/threonine protein kinase activity, interacts with RIPK1 to …