Introduction Patients with Human Hyper IgM syndromes (HIGM) developed pulmonary and
gastrointestinal infections since infancy and most patients have mutations in the CD40 …

CD4+ T cells have orchestrated and regulated immunity since the introduction of jawed
vertebrates, yet our understanding of CD4+ T cell evolution, development, and cellular …

Tricho-hepato-enteric syndrome (THES)(OMIM# 222,470) is a rare autosomal recessive
syndromic enteropathy whose primary manifestations are dysmorphism, intractable …

Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is
selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell …

Background X‐linked hyper‐IgM (X‐HIGM), which results from mutations in the CD40LG
gene located on chromosome Xq26. 3, is the most common form of HIGM. To date, more …

Liposomes have received tremendous attention as a class of versatile pharmaceutical
vehicles of great potential over the past several decades. However, the application of …

Interventions: He was treated with trimethoprim/sulfamethoxazole for PCP, and eventually
received allogeneic hematopoietic cell transplantation for hyper-IgM syndrome. Outcomes …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune-mediated disease
that affects patients with known genetic defects and is increasingly found among those with …

Very high IgM levels represent the hallmark of hyper IgM (HIGM) syndromes, a group of
primary immunodeficiencies (PIDs) characterized by susceptibility to infections and …

An approximately 1‐year‐old male intact Shih Tzu dog was referred to a tertiary facility with
a history of progressive tachypnea, increased respiratory effort, and weight loss over a 3 …