Highlights•Review summarizes the current status of colon cancer and its management
strategies.•Features nanoformulated targeted delivery of anticancer drugs for colon cancer …

The field of drug discovery has witnessed infinite development over the last decade with the
demand for discovery of novel efficient lead compounds. Although the development of novel …

Colorectal cancer (CRC) is characterized by recurrent mutations deregulating key cell
signaling cascades and providing the cancer cells with novel functional traits. Among the …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Mutations in the KRAS oncogene represent one of the most prevalent genetic alterations in
colorectal cancer (CRC), the third leading cause of cancer-related death in the US. In …

Polymeric nanoparticles for colon cancer therapy: overview and perspectives - Journal of
Materials Chemistry B (RSC Publishing) DOI:10.1039/C6TB01925K Royal Society of …

Purpose: Targeted inhibition of EGFR with the mAbs cetuximab or panitumumab is a
valuable treatment for RAS wild-type colorectal cancers. The efficacy of EGFR blockade is …

W ith the upsurge of personalizing virtually anything such as mugs, stationery, T‑shirts,
phone cases, gift items and most recently the ongoing personalized Coca‑Cola UK summer …

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that
allows for modulating the activity of local neural populations and related neural networks …

Tumors consist of different genotypically distinct subpopulations—or subclones—of cells.
These subclones can influence neighboring clones in a process called “clonal interaction.” …