There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Targeted protein degradation (TPD) has emerged as the most promising approach for the
specific knockdown of disease-associated proteins and is achieved by exploiting the cellular …

In this work, N-benzylarylamide-dithiocarbamate based derivatives were designed,
synthesized, and their biological activities as anticancer agents were explored. Some of the …

Tremendous research is focused on developing novel drug candidates targeting
microtubules to inhibit their function in several cellular processes, including cell division. In …

Preclinical and clinical studies have demonstrated the synergistic effect of microtubule-
targeting agents in combination with Janus kinase 2 (JAK2) inhibitors, prompting the …

Microtubule targeting agents (MTAs) are used as clinically effective chemotherapies for
cancer treatment but might be limited by the acquired or intrinsic resistance of cancer cells to …

Epigenetic regulation and Focal adhesion kinase (FAK) are considered to be two important
targets for the development of antitumor drugs. Studies have shown that the combination of …