The wide use and abuse of antibiotics could make antimicrobial resistance (AMR) an
increasingly serious issue that threatens global health and imposes an enormous burden on …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …

Objectives Sepsis guidelines recommend obtaining blood cultures before starting anti-
infective therapy in patients with sepsis. However, little is known of how antibiotic treatment …

Sepsis is an often fatal condition that arises when the immune response to an infection
causes widespread systemic organ injury. A critical unmet need in combating sepsis is the …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …

Introduction: Despite advances in modern medicine, severe community-acquired
pneumonia (CAP) continues to be a potentially deadly disease. Mortality rate reaches up to …

Background The objective of this study was to explore the diagnostic and prognostic value of
soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of …

One can falsely assume that it is well known that bacteremia is associated with higher
mortality in sepsis. Only a handful of studies specifically focus on the comparison of culture …

Systemic levels of cytokines are altered during infection and sepsis. This prospective
observational study aimed to investigate whether plasma levels of multiple inflammatory …

The standardization of the Intensive Care Medicine may improve the management of the
adult critically ill patient. However, these strategies have not been widely applied in the …