Purpose The objective of this study was to define the maximum-tolerated dose (MTD), the
recommended phase II dose, the dose-limiting toxicity, and determine the pharmacokinetic …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

Histone deacetylase (HDACs) regulate histone acetylation by catalyzing the removal of
acetyl groups on the NH2-terminal lysine residues of the core nucleosomal histones …

Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer
treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of …

Epigenetic mechanisms are involved in regulating chromatin structure and gene expression
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …

Modulation of chromatin structure through histone acetylation/deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …

Epigenetic regulation of gene expression is mediated through alterations in the DNA
methylation status, covalent modifications of core nucleosomal histones, rearrangement of …

Histone acetylation modulates gene expression, cellular differentiation, and survival and is
regulated by the opposing activities of histone acetyltransferases (HATs) and histone …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …

Genetic variations along with epigenetic modifications of DNA are involved in colorectal
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …