Infectious agents can trigger autoimmune responses in a number of chronic inflammatory
diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia …

Background: Lyme borreliosis (LB) is the most common tick-borne disease in Europe, but
the burden of disease is incompletely described. Methods: We conducted a systematic …

Cardiac involvement is a rare but relevant manifestation of Lyme disease that frequently
presents as atrioventricular block (AVB). Immune-mediated injury has been implicated in the …

Lyme disease is the most common vector-borne disease in North America and Europe. The
clinical manifestations of Lyme disease vary based on the genospecies of the infecting …

Modern infectious disease outbreaks often involve changes in host tropism, the preferential
adaptation of pathogens to specific hosts. The Lyme disease-causing bacterium Borrelia …

The RNA polymerase alternative σ factor RpoS in Borrelia burgdorferi (Bb), the Lyme
disease pathogen, is responsible for programmatic-positive and-negative gene regulation …

Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-
borne illness in the United States. Many aspects of the disease are still topics of controversy …

Introduction The incidence of Lyme disease (LD) in Canada and the United States has risen
over the last decade, nearing 480,000 cases each year. Borrelia burgdorferi sensu lato, the …

The annual incidence of Lyme disease, caused by tick-transmitted Borreliella burgdorferi, is
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …

Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host
innate immune system, including the complement cascade. The Lyme disease spirochete …