Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD)
properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Background β-Lactams are routinely used as empirical therapy in critical illness, with
extended concentrations above the minimum inhibitory concentration (MIC) of the infecting …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

Background Correct antibiotic dosing remains a challenge for the clinician. The aim of this
study was to assess the influence of augmented renal clearance on pharmacokinetic …

Objective: The clinical benefits of extended infusion or continuous infusion of β-lactam
antibiotics remain controversial. We systematically reviewed the literature to determine …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …