Precision medicine approaches to overcome resistance to therapy in head and neck cancers

S Ortiz-Cuaran, J Bouaoud, A Karabajakian… - Frontiers in …, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

[HTML][HTML] Advances in the management of squamous cell carcinoma of the head and neck

JP Machiels, M Lambrecht, FX Hanin, T Duprez… - F1000prime …, 2014 - ncbi.nlm.nih.gov
Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer
worldwide. The main risk factors for cancers of the oral cavity, larynx, oropharynx, and …

[HTML][HTML] Unraveling the molecular genetics of head and neck cancer through genome-wide approaches

N Riaz, LG Morris, W Lee, TA Chan - Genes & diseases, 2014 - Elsevier
The past decade has seen an unprecedented increase in our understanding of the biology
and etiology of head and neck squamous cell carcinomas (HNSCC). Genome-wide …

Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer

SB Mali - Oral oncology, 2015 - Elsevier
STATs can be activated independently of JAKs, most notably by c-Src kinases. In cancer
cells, STAT3 and STAT5 activation leads to the increased expression of downstream target …

Oral cancer: genetics and the role of precision medicine

CC Li, Z Shen, R Bavarian, F Yang… - Dental …, 2018 - dental.theclinics.com
Dent Clin N Am 62 (2018) 29–46 http://dx. doi. org/10.1016/j. cden. 2017.08. 002 dental.
theclinics. com 0011-8532/18/© 2017 Elsevier Inc. All rights reserved. diagnosed cancer …

A YAP/TAZ-regulated molecular signature is associated with oral squamous cell carcinoma

SE Hiemer, L Zhang, VK Kartha, TS Packer… - Molecular Cancer …, 2015 - AACR
Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the
epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with …

Survival-associated metabolic genes in human papillomavirus-positive head and neck cancers

MA Prusinkiewicz, SF Gameiro, F Ghasemi, MJ Dodge… - Cancers, 2020 - mdpi.com
Human papillomavirus (HPV) causes an increasing number of head and neck squamous
cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the …

Dental management of patients who have undergone oral cancer therapy

A Villa, SO Akintoye - Dental Clinics, 2018 - dental.theclinics.com
Oral cancers remain a major health concern worldwide. The tumor-related and
patientrelated factors, as well as treatment complications, negatively affect the 5-year …

Early detection and personalized treatment in oral cancer: the impact of omics approaches

IP Ribeiro, L Barroso, F Marques, JB Melo… - Molecular …, 2016 - Springer
Background Oral cancer is one of the most common malignant lesions of the head and neck.
This cancer is an aggressive and lethal disease with no significant improvements in the …

Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis

L Cui, X Zhao, Z Jin, H Wang… - Journal of Pineal …, 2021 - Wiley Online Library
Metabolic remodeling is now widely recognized as a hallmark of cancer, yet its role in head
and neck squamous cell carcinoma (HNSCC) remains largely unknown. In this study …