Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Management of hepatocellular carcinoma in Japan: JSH consensus statements and recommendations 2021 update

M Kudo, Y Kawamura, K Hasegawa, R Tateishi… - Liver cancer, 2021 - karger.com
Abstract The Clinical Practice Manual for Hepatocellular Carcinoma was published based
on evidence confirmed by the Evidence-based Clinical Practice Guidelines for …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

JM Llovet, T De Baere, L Kulik, PK Haber… - Nature reviews …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality and
has an increasing incidence worldwide. Locoregional therapies, defined as imaging-guided …

Targeted therapy for hepatocellular carcinoma

A Huang, XR Yang, WY Chung, AR Dennison… - Signal transduction and …, 2020 - nature.com
The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …

[HTML][HTML] 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights

DY Xie, ZG Ren, J Zhou, J Fan… - Hepatobiliary surgery and …, 2020 - ncbi.nlm.nih.gov
2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates
and insights - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

90Y Radioembolization versus Drug-eluting Bead Chemoembolization for Unresectable Hepatocellular Carcinoma: Results from the TRACE …

E Dhondt, B Lambert, L Hermie, L Huyck… - Radiology, 2022 - pubs.rsna.org
Background Transarterial chemoembolization (TACE) is the recommended treatment for
intermediate hepatocellular carcinoma (HCC) according to the Barcelona Clinic Liver …

Molecular therapies and precision medicine for hepatocellular carcinoma

JM Llovet, R Montal, D Sia, RS Finn - Nature reviews Clinical oncology, 2018 - nature.com
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular …

M Kudo, K Ueshima, M Ikeda, T Torimura, N Tanabe… - Gut, 2020 - gut.bmj.com
Objective This trial compared the efficacy and safety of transarterial chemoembolisation
(TACE) plus sorafenib with TACE alone using a newly established TACE-specific endpoint …

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

AL Cheng, C Hsu, SL Chan, SP Choo, M Kudo - Journal of hepatology, 2020 - Elsevier
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-
1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at …