Mathematical models of biological systems often have components that vary on different
timescales. This multi-timescale character can lead to problems when doing computer …

Both endocrine and non-endocrine cells of the pituitary gland are organized into structural
and functional networks which are formed during embryonic development but which may be …

Understanding the physiology and pathology of an organ composed of a variety of cell
populations depends critically on genome-wide information on each cell type. Here, we …

Hormone rhythms are ubiquitous and essential to sustain normal physiological functions.
Combined mathematical modelling and experimental approaches have shown that these …

The mammalian pituitary gland is a complex organ consisting of hormone‐producing cells,
anterior lobe folliculostellate cells (FSCs), posterior lobe pituicytes, vascular pericytes and …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

The discoveries of novel functional adaptations of the hypothalamus and anterior pituitary
gland for physiological regulation have transformed our understanding of their interaction …

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to
gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH …

Experience-dependent plasticity of cell and tissue function is critical for survival by allowing
organisms to dynamically adjust physiological processes in response to changing or harsh …

An action potential is a rapid sequence of changes in the voltage across a membrane. The
membrane voltage, or potential, is determined at any time by the relative ratio of ions …