The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses
Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice
KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Dengue mouse models for evaluating pathogenesis and countermeasures
RE Chen, MS Diamond - Current opinion in virology, 2020 - Elsevier
Dengue virus (DENV) causes the most prevalent arbovirus illness worldwide and is
responsible for many debilitating epidemics. The four circulating DENV serotypes infect …
responsible for many debilitating epidemics. The four circulating DENV serotypes infect …
The diversity outbred mouse population is an improved animal model of vaccination against tuberculosis that reflects heterogeneity of protection
Many studies of Mycobacterium tuberculosis infection and immunity have used mouse
models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred …
models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred …
A multitrait locus regulates sarbecovirus pathogenesis
Infectious diseases have shaped the human population genetic structure, and genetic
variation influences the susceptibility to many viral diseases. However, a variety of …
variation influences the susceptibility to many viral diseases. However, a variety of …
Update on and future directions for use of anti–SARS-CoV-2 antibodies: National Institutes of Health Summit on Treatment and Prevention of COVID-19
C Boggiano, RW Eisinger, AM Lerner… - Annals of internal …, 2022 - acpjournals.org
As the fourth wave of the SARS-CoV-2 pandemic encircles the globe, there remains an
urgent challenge to identify safe and effective treatment and prevention strategies that can …
urgent challenge to identify safe and effective treatment and prevention strategies that can …
Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice
JB Graham, JL Swarts, SR Leist, A Schäfer… - PLoS …, 2021 - journals.plos.org
The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide
range of clinical outcomes in humans. An incomplete understanding of immune correlates of …
range of clinical outcomes in humans. An incomplete understanding of immune correlates of …
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
AJ Brown, JJ Won, R Wolfisberg, U Fahnøe… - Hepatology, 2024 - journals.lww.com
Abstract Background & Aims: Human genetic variation is thought to guide the outcome of
HCV infection, but model systems within which to dissect these host genetic mechanisms …
HCV infection, but model systems within which to dissect these host genetic mechanisms …
Thirdhand tobacco smoke exposure increases the genetic background-dependent risk of pan-tumor development in Collaborative Cross mice
H Yang, X Wang, P Wang, L He, SF Schick… - Environment …, 2023 - Elsevier
Increasing evidence has shown that thirdhand smoke (THS) exposure is likely to induce
adverse health effects. An important knowledge gap remains in our understanding of THS …
adverse health effects. An important knowledge gap remains in our understanding of THS …
Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection
The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study
innate immunity against microbial pathogens. C. elegans have been collected from around …
innate immunity against microbial pathogens. C. elegans have been collected from around …