Addictive drugs share with palatable food the property of increasing extracellular dopamine
(DA), preferentially in the nucleus accumbens shell rather than in the core. However, by …

The discovery of dopamine as a neurotransmitter in brain by Arvid Carlsson approximately
50 years ago, and the subsequent insight provided by Paul Greengard into the cellular …

Rationale Animal experiments have provided evidence that the striatum and medial
prefrontal cortex play a predominant role in the acquisition and maintenance of drug …

Imaging studies have provided evidence of how the human brain changes as an individual
becomes addicted. Here, we integrate the findings from imaging studies to propose a model …

Decisions about using addictive substances are influenced by distractions by addiction-
related stimuli, of which the user might be unaware. The addiction-Stroop task is a paradigm …

Goal-directed behavior is believed to involve interactions of prefrontal cortical and limbic
inputs in the nucleus accumbens (NAcc), and their modulation by mesolimbic dopamine …

Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …

What is the role of dopamine in natural rewards? A genetic mutant approach was taken to
examine the consequences of elevated synaptic dopamine on (1) spontaneous food and …

One of the defining characteristics of the research of Ann E. Kelley was her recognition that
the neuroscience underlying basic learning and motivation processes also shed significant …

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease …