Objective: The purpose of this article is to review some of the basic aspects of the
dopaminergic system and its role in reward and pleasure behaviour. We also discuss the …

Over the last few decades, advances in human and animal‐based techniques have greatly
enhanced our understanding of the neural mechanisms underlying psychiatric disorders …

Serotonin1A-receptors (5-HT1A-Rs) are important components of the 5-HT system in the
brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as …

The neurobiological processes by which ethanol seeking and consumption are established
and maintained are thought to involve areas of the brain that mediate motivated behavior …

Numerous research has pointed out that serotonin2c (5-HT2C) receptor, a subtype of 5-HT
receptors belonging to the G-protein-coupled receptor superfamily, modulates the activity of …

It is now widely accepted that nicotine is the primary addictive component of tobacco smoke
and that a majority of habitual smokers find it difficult to quit smoking because of their …

A common criticism of the Diagnostic and Statistical Manual of Mental Disorders (American
Psychiatric Association, 2013) is that its criteria are based more on behavioral descriptions …

Recent advances in the fields of genetics, molecular biology, behavioral
neuropharmacology, and brain imaging have dramatically changed our understanding of …

Adaptive motivated behaviors are at the core of a successful life. Conversely, perturbed
motivated behaviors are the hallmark of psychiatric disorders. Based on the notion that most …

Histotechnological breakthroughs in the late 1960s paved the way for anatomical
discoveries that led to the concepts of the ventral striatal-pallidal system and the extended …