The delivery of biologic cargoes to airway epithelial cells is challenging due to the
formidable barriers imposed by its specialized and differentiated cells. Among cargoes …

Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Glioblastoma multiforme (GBM) is one of the most aggressive cancers, where the
aggressiveness of tumor has been associated to its high vascularization rate. Bevacizumab …

There are more amino acid permutations within a 40-residue sequence than atoms on Earth.
This vast chemical search space hinders the use of human learning to design functional …

This book explains the role of hormones in improving and monitoring the production,
performance, reproduction, behaviour and health of livestock animals, focusing on cattle …

Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …

Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene
generating a great hope due to their outstanding specificity and potency. However, given …

Self-assembling proteins are valuable building blocks for constructing drug nanocarriers
due to their self-assembly behavior, monodispersity, biocompatibility, and biodegradability …

Intracellular protein delivery is a powerful strategy for developing innovative therapeutics.
Nanocarriers present great potential to deliver proteins inside cells by promoting cellular …