Remote triggering of contents release with micron spatial and sub-second temporal
resolution has been a long-time goal of medical and technical applications of liposomes …

With more than 90 approved drugs by 2020, therapeutic antibodies have played a central
role in shifting the treatment landscape of many diseases, including autoimmune disorders …

Antibodies can be developed to directly inhibit almost any protein, but their inability to enter
the cytosol limits inhibitory antibodies to membrane-associated or extracellular targets …

Amyotrophic Lateral Sclerosis (ALS) is a mid-life onset neurodegenerative disease that
manifests its symptomatology with motor impairments and cognitive deficits overlapping with …

Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for
biomedical research and the pharmaceutical industry. Approximately two-thirds of disease …

Antibodies are being increasingly used for therapeutic purposes due to their remarkable
target specificity and affinity. However, currently available antibody therapies are restricted …

Aggregated α-synuclein, a major constituent of Lewy bodies plays a crucial role in the
pathogenesis of α-synucleinopathies (SPs) such as Parkinson's disease (PD). PD is affected …

Coarse-grained (CG) modelling with the Martini force field has come of age. By combining a
variety of bead types and sizes with a new mapping approach, the newest version of the …

Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage
in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its …

Introduction Monoclonal antibodies have been utilized in clinical and basic research for the
treatment of various malignancies. Whilst all therapeutically approved monoclonal …