The epidermal growth factor receptor (EGFR) has been recognized as an important
therapeutic target in oncology. It is commonly overexpressed in a variety of solid tumors and …

The intricate relationship between anti-tumor immunity and autoimmunity is a complex yet
crucial aspect of cancer biology. Tumor microenvironment often exhibits autoimmune …

Breast cancer is a heterogeneous disease, which is the consequence of several genetic and
environmental factors. Also, it is one of the most common causes of cancer death and …

Peptides and proteins represent an emerging class of powerful therapeutics. Peptide and
protein nanogels are attractive carriers for the transport and delivery of biologically active …

A new vehicle is designed for the intracellular delivery of antibodies at nanomolar
concentrations by combination of domain Z, a small affibody with strong binding affinity to Fc …

Transcription factors (TFs) and RNA-binding proteins (RBPs) have long been considered
undruggable, mainly because they lack ligand-binding sites and are equipped with flat and …

Nanoparticles-mediated photoporation has arisen as universal intracellular delivery tool;
however, the direct interaction of nanoparticles and cells hampers its clinical translation …

Most antibodies currently in use have been selected based on their binding affinity.
However, nowadays, antibodies that can not only bind but can also alter the function of cell …

Neutrophils are not only involved in immune defense against infection but also contribute to
the exacerbation of tissue damage after ischemia and reperfusion. We have previously …

The application and design of protein transduction domains (PTDs) and protein transduction
domain mimics (PTDMs) have revolutionized the field of biomacromolecule delivery. Our …