Tissue clearing and its applications in neuroscience
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …
tissues from individual organs and even to some entire mammals. When combined with light …
[HTML][HTML] Whole-brain profiling of cells and circuits in mammals by tissue clearing and light-sheet microscopy
Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …
have been combined only recently to facilitate novel experiments and measurements in …
[HTML][HTML] An organic artificial spiking neuron for in situ neuromorphic sensing and biointerfacing
The effective mimicry of neurons is key to the development of neuromorphic electronics.
However, artificial neurons are not typically capable of operating in biological environments …
However, artificial neurons are not typically capable of operating in biological environments …
Intracellular chloride regulation mediates local sleep pressure in the cortex
Extended wakefulness is associated with reduced performance and the build-up of sleep
pressure. In the cortex, this manifests as changes in network activity. These changes show …
pressure. In the cortex, this manifests as changes in network activity. These changes show …
[HTML][HTML] Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues
Whole-organ/body three-dimensional (3D) staining and imaging have been enduring
challenges in histology. By dissecting the complex physicochemical environment of the …
challenges in histology. By dissecting the complex physicochemical environment of the …
[HTML][HTML] Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways
Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological
activity, underlies several critical functions, including learning and memory. However, NREM …
activity, underlies several critical functions, including learning and memory. However, NREM …
A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing
A three-dimensional single-cell-resolution mammalian brain atlas will accelerate systems-
level identification and analysis of cellular circuits underlying various brain functions …
level identification and analysis of cellular circuits underlying various brain functions …
[HTML][HTML] Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
Abstract Information transfer within neuronal circuits depends on the balance and recurrent
activity of excitatory and inhibitory neurotransmission. Chloride (Cl−) is the major central …
activity of excitatory and inhibitory neurotransmission. Chloride (Cl−) is the major central …
[HTML][HTML] The biological function of the cellular prion protein: an update
MA Wulf, A Senatore, A Aguzzi - BMC biology, 2017 - Springer
The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
[HTML][HTML] Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale
The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …
calcium channels. Initially licensed for pain and seizures, they have become widely …