Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Derangements in cerebrovascular structure and function can impair cognitive performance
throughout ageing and in cardiometabolic disease states, thus increasing dementia risk …

The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

Most reactive oxygen species (ROS) are generated in cells by the mitochondrial respiratory
chain. Mitochondrial ROS production is modulated largely by the rate of electron flow …

The brain is one of the most exquisite organs in the body with high metabolic demands, and
requires a tight regulation of the surrounding environment. This tight control is exerted by the …

J. Neurochem.(2010) 115, 814–828. Abstract Vascular cognitive impairment (VCI)
encompasses vascular dementia and is the second most common cause of dementing …

Vascular endothelial dysfunction is regarded as a primary phenotypic expression of normal
human aging. This senescence-induced disorder is the likely culprit underlying the …

Accumulating evidence suggests that cerebrovascular dysfunction is an important factor in
the pathogenesis of Alzheimer's disease (AD). Using aged (∼ 16 months) amyloid precursor …