Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

MJF Levy, F Boulle, HW Steinbusch… - …, 2018 - Springer
Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Post stroke depression: the sequelae of cerebral stroke

J Das, GK Rajanikant - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
Post-stroke depression (PSD) is the most common mental health issue, afflicting around
33% of stroke survivors. PSD has a negative impact on the rehabilitation, recuperation of …

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

L Schmaal, DJ Veltman, TGM van Erp… - Molecular …, 2016 - nature.com
The pattern of structural brain alterations associated with major depressive disorder (MDD)
remains unresolved. This is in part due to small sample sizes of neuroimaging studies …

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

L Schmaal, E Pozzi, T C. Ho, LS Van Velzen… - Translational …, 2020 - nature.com
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

Antidepressants for the treatment of depression in people with cancer

G Ostuzzi, F Matcham, S Dauchy… - Cochrane Database …, 2018 - cochranelibrary.com
Background Major depression and other depressive conditions are common in people with
cancer. These conditions are not easily detectable in clinical practice, due to the overlap …

BDNF/NF-κB signaling in the neurobiology of depression

A Caviedes, C Lafourcade, C Soto… - Current …, 2017 - ingentaconnect.com
Background: Mood disorders, consisting of unipolar and bipolar depression, are complex
diseases characterized by depressed mood and anhedonia. These core symptoms are …

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Effects of diet on brain plasticity in animal and human studies: mind the gap

T Murphy, GP Dias, S Thuret - Neural plasticity, 2014 - Wiley Online Library
Dietary interventions have emerged as effective environmental inducers of brain plasticity.
Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a …

Activity-dependent neural plasticity from bench to bedside

K Ganguly, M Poo - Neuron, 2013 - cell.com
Much progress has been made in understanding how behavioral experience and neural
activity can modify the structure and function of neural circuits during development and in the …

Gene expression in major depressive disorder

R Jansen, B Penninx, V Madar, K Xia… - Molecular …, 2016 - nature.com
The search for genetic variants underlying major depressive disorder (MDD) has not yet
provided firm leads to its underlying molecular biology. A complementary approach is to …