[HTML][HTML] Diet and microbiota in inflammatory bowel disease: The gut in disharmony
DCM Rapozo, C Bernardazzi… - World journal of …, 2017 - ncbi.nlm.nih.gov
Bacterial colonization of the gut shapes both the local and the systemic immune response
and is implicated in the modulation of immunity in both healthy and disease states. Recently …
and is implicated in the modulation of immunity in both healthy and disease states. Recently …
[HTML][HTML] Genetic and epigenetic etiology of inflammatory bowel disease: An update
S Jarmakiewicz-Czaja, M Zielińska, A Sokal, R Filip - Genes, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …
[HTML][HTML] DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes …
Background & Aims We analyzed DNA methylation patterns and transcriptomes of primary
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …
[PDF][PDF] Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn's disease
Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …
[HTML][HTML] Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Background The interplay of epigenetic processes and the intestinal microbiota may play an
important role in intestinal development and homeostasis. Previous studies have …
important role in intestinal development and homeostasis. Previous studies have …
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development
Objective Human intestinal epithelial organoids (IEOs) are increasingly being recognised as
a highly promising translational research tool. However, our understanding of their …
a highly promising translational research tool. However, our understanding of their …
[HTML][HTML] New insights into the epigenetic regulation of inflammatory bowel disease
J Xu, H Xu, M Yang, Y Liang, Q Peng… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …
Environmental factors, genetics, intestinal microbiota, and the immune system are all …
[HTML][HTML] The role of epigenetic modifications for the pathogenesis of Crohn's disease
M Hornschuh, E Wirthgen, M Wolfien, KP Singh… - Clinical …, 2021 - Springer
Epigenetics has become a promising field for finding new biomarkers and improving
diagnosis, prognosis, and drug response in inflammatory bowel disease. The number of …
diagnosis, prognosis, and drug response in inflammatory bowel disease. The number of …
Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium
O Kayisoglu, F Weiss, C Niklas, I Pierotti, M Pompaiah… - Gut, 2021 - gut.bmj.com
Objective The epithelial layer of the GI tract is equipped with innate immune receptors to
sense invading pathogens. Dysregulation in innate immune signalling pathways is …
sense invading pathogens. Dysregulation in innate immune signalling pathways is …
[HTML][HTML] Inflammatory auto-immune diseases of the intestine and their management by natural bioactive compounds
Autoimmune diseases are caused by the overactivity of the immune system towards self-
constituents. Risk factors of autoimmune diseases are multiple and include genetic …
constituents. Risk factors of autoimmune diseases are multiple and include genetic …