Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Pharmacological inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are now an
established standard of care for patients with advanced hormone receptor-positive breast …

Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Endothelial cells line the blood and lymphatic vasculature, and act as an essential physical
barrier, control nutrient transport, facilitate tissue immunosurveillance and coordinate …

The growth of artificial intelligence (AI) has led to an increase in the adoption of computer
vision and deep learning (DL) techniques for the evaluation of microscopy images and …

The cell cycle is the series of events that occur in a cell leading to its division and
duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the …

In metastatic breast cancer, HER2-activating mutations frequently co-occur with mutations in
PIK3CA, TP53, or CDH1. Of these co-occurring mutations, HER2 and PIK3CA are the most …

Triple negative breast cancer (TNBC) remains exceptionally challenging to treat. While
CDK4/6 inhibitors have revolutionized HR+ breast cancer therapy, there is limited …

Cell cycle dysregulation is a hallmark of cancer that promotes eccessive cell division. Cyclin-
dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) are key molecules in …

In this study, we have devised a computational framework called Supervised Feature
Learning and Scoring (SuperFeat) that allows for the training of a machine learning model …