In this study, we have devised a computational framework SuperFeat that allows for the
training of a machine learning model and evaluate the canonical cellular states/features in …

Die ICB hat die Therapie des metastasierten malignen Melanoms revolutioniert und
zeichnet sich durch vergleichsweise hohe Ansprechraten aus. Notwendig für das …

Chemotherapy treatment elicits a variety of cellular responses such as reversible cell-cycle
exit (quiescence) and irreversible arrest (senescence). However, distinguishing between the …

Attempts to map the Restriction Point in the mammalian cell cycle typically involve
stimulating quiescent cells with mitogens for increasing intervals, removing the stimulus and …

Treating pediatric, adolescent, and young adult (AYA) osteosarcoma (OS) is challenging
due to its aggressiveness, genetic complexity, lack of standard therapies, and chemotherapy …

A fundamental hallmark of cancer is the cell's ability to sustain proliferative signaling thereby
deregulating the cell cycle. Uncovering the molecular changes that inappropriately drive …

Our previous work had suggested that LncRNA SNHG6 interacted with COPS5 and their
expression was positively correlated in hepatocellular carcinoma (HCC). In this study we …

Nowadays, oncogenic proteins have been widely discovered and identified, scarcely ever
oncogenic proteins can be well applied as drug targets, which is a difficult problem for …

Abstract The Fluorescence Ubiquitination-based Cell Cycle Indicator (FUCCI system) is a
tool used to visualize the cell cycle phases of living cells in real time. The method is based …