Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment
M Zhang, W Hu, C Cai, Y Wu, J Li, S Dong - Materials Today Bio, 2022 - Elsevier
Inflammatory arthritis is a major cause of disability in the elderly. This condition causes joint
pain, loss of function, and deterioration of quality of life, mainly due to osteoarthritis (OA) and …
pain, loss of function, and deterioration of quality of life, mainly due to osteoarthritis (OA) and …
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages
Y Hu, Z Gui, Y Zhou, L Xia, K Lin, Y Xu - Free Radical Biology and …, 2019 - Elsevier
Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …
Radical-scavenging and subchondral bone-regenerating nanomedicine for osteoarthritis treatment
H Lu, J Wei, K Liu, Z Li, T Xu, D Yang, Q Gao, H Xiang… - ACS …, 2023 - ACS Publications
Osteoarthritis (OA) is characterized by cartilage degradation and subchondral bone
remodeling. However, most available studies focus on either cartilage degradation or …
remodeling. However, most available studies focus on either cartilage degradation or …
Chitosan oligosaccharide: Biological activities and potential therapeutic applications
C Muanprasat, V Chatsudthipong - Pharmacology & therapeutics, 2017 - Elsevier
Chitosan oligosaccharide (COS) is an oligomer of β-(1➔ 4)-linked d-glucosamine. COS can
be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the …
be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the …
Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature
Abstract Background Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized
by a complex and multifactorial nature. It has been hypothesised that these differences are …
by a complex and multifactorial nature. It has been hypothesised that these differences are …
Mesenchymal stem cell therapy for osteoarthritis: the critical role of the cell secretome
P Mancuso, S Raman, A Glynn, F Barry… - … in bioengineering and …, 2019 - frontiersin.org
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments.
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …
Knee osteoarthritis: a review of management options
SM Hussain, DW Neilly, S Baliga… - Scottish medical …, 2016 - journals.sagepub.com
Osteoarthritis of the knee is a complex peripheral joint disorder with multiple risk factors. The
molecular basis of osteoarthritis has been generally accepted; however, the exact …
molecular basis of osteoarthritis has been generally accepted; however, the exact …