[HTML][HTML] The controversial role of human gut lachnospiraceae
The complex polymicrobial composition of human gut microbiota plays a key role in health
and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal …
and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal …
Crohn's disease
G Roda, S Chien Ng, PG Kotze, M Argollo… - Nature Reviews …, 2020 - nature.com
Crohn's disease is an inflammatory bowel disease that is characterized by chronic
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: results from an international …
Background and Aims The impact of Coronavirus disease 2019 (COVID-19) on patients with
inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course …
inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course …
[HTML][HTML] IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
M Friedrich, M Pohin, MA Jackson, I Korsunsky… - Nature Medicine, 2021 - nature.com
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …
Effect of IBD medications on COVID-19 outcomes: results from an international registry
Objective We sought to evaluate COVID-19 clinical course in patients with IBD treated with
different medication classes and combinations. Design Surveillance Epidemiology of …
different medication classes and combinations. Design Surveillance Epidemiology of …
How autophagy controls the intestinal epithelial barrier
EG Foerster, T Mukherjee, L Cabral-Fernandes… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …
mediated recycling of organelles and protein aggregates, as well as the destruction of …
The epidemiology of inflammatory bowel disease: East meets west
The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade
to become a global disease. The increasing number of studies on the incidence and course …
to become a global disease. The increasing number of studies on the incidence and course …
[PDF][PDF] Targeting interleukin-6 signaling in clinic
S Kang, T Tanaka, M Narazaki, T Kishimoto - Immunity, 2019 - cell.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
AGA clinical practice guidelines on the medical management of moderate to severe luminal and perianal fistulizing Crohn's disease
JD Feuerstein, EY Ho, E Shmidt, H Singh… - …, 2021 - gastrojournal.org
Methods This document presents the official recommendations of the AGA on the medical
management of moderate to severe luminal and fistulizing CD in adults. This guideline …
management of moderate to severe luminal and fistulizing CD in adults. This guideline …
[PDF][PDF] Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …
patients. Here, we applied single-cell technologies to iCD lesions to address whether …