Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET
cellular proto-oncogene, are expressed in the nervous system from pre-natal development …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …

Microglia, the principal neuroimmune sentinels of the brain, continuously sense changes in
their environment and respond to invading pathogens, toxins and cellular debris. Microglia …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

Effective stroke therapies require recanalization of occluded cerebral blood vessels.
However, reperfusion can cause neurovascular injury, leading to cerebral edema, brain …

Axon regeneration constitutes a fundamental challenge for regenerative neurobiology,
which necessitates the use of tailor-made biomaterials for controllable delivery of cells and …

Understanding axon regenerative failure remains a major goal in neuroscience, and
reversing this failure remains a major goal for clinical neurology. Although an inhibitory …

Background Systemic inflammation induces neuroinflammation and cellular changes such
as tau phosphorylation to impair cognitive function, including learning and memory. This …

Ischemic stroke results in demyelination that underlies neurological disfunction. Promoting
oligodendrogenesis will rescue the injured axons and accelerate remyelination after stroke …

Cerebral ischemia and reperfusion increase superoxide anions (O2·−) in brain
mitochondria. Manganese superoxide dismutase (Mn-SOD; SOD2), a primary mitochondrial …