Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are
sensitive to changes in the concentrations of circulating thyroid hormones. The importance …

Thyroid hormone has many effects on the heart and vascular system. 1 Many of the clinical
manifestations of hyperthyroidism are due to the ability of thyroid hormone to alter …

Thyroid hormones have long been known to have a range of effects on the cardiovascular
system. However, significant knowledge gaps exist concerning the precise molecular and …

Subclinical thyroid disease (SCTD) is defined as serum free T4 and free T3 levels within
their respective reference ranges in the presence of abnormal serum TSH levels. SCTD is …

This autopsy finding of diffuse atherosclerosis in a 58-yrold woman was published as an
appendix to William Ord's classical description of the syndrome of myxedema. Soon …

The heart is a major target organ for thyroid hormone action, and marked changes occur in
cardiac function in patients with hypo-or hyperthyroidism. T3-induced changes in cardiac …

According to the traditional model, steroid hormones bind to intracellular receptors and
subsequently modulate transcription and protein synthesis, thus triggering genomic events …

Increased or reduced action of thyroid hormone on certain molecular pathways in the heart
and vasculature causes relevant cardiovascular derangements. It is well established that …

The cardiovascular risk in patients with hypothyroidism is related to an increased risk of
functional cardiovascular abnormalities and to an increased risk of atherosclerosis. The …

The thyroid hormones are very hydrophobic and those that exhibit biological activity are 3′,
5′, 3, 5-L-tetraiodothyronine (T4), 3′, 5, 3-L-triiodothyronine (T3), 3′, 5′, 3-L …