Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Meropenem dosing in critically ill patients with septic shock and continuous renal
replacement therapy (CRRT) is complex, with the recommended maintenance doses being …

Prolonged infusion of β-lactam antibiotics as either extended (over at least 2 hours) or
continuous infusion is increasingly applied in intensive care units around the world in an …

Sepsis is a life-threatening response to infection that contributes significantly to neonatal
and pediatric morbidity and mortality worldwide. The key tenets of care include early …

OBJECTIVES: Patients with infection can develop sepsis, and their mortality can be high. An
important aspect in the treatment of sepsis is adequate management of the infection. DATA …

Background Appropriate antimicrobial dosing is challenging because of changes in
pharmacokinetics (PK) parameters and an increase in multidrug-resistant (MDR) organisms …

This study investigates the optimal meropenem (MEM) dosing regimen for critically ill
pediatric patients, for which there is a lack of pharmacokinetic (PK) studies. We conducted a …

Abstract Purpose of Review Beta-lactam antibiotics are commonly prescribed in critically ill
patients for a variety of infectious conditions. Our understanding of how critical illness alters …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …