Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that progressively and
irreversibly alters the lung parenchyma, eventually leading to respiratory failure. The study of …

Transplantation is the only long-term treatment option for patients with end-stage lung and
tracheal diseases. However, transplantation is limited by shortage of donor organs and post …

Experimental models are critical for the understanding of lung health and disease and are
indispensable for drug development. However, the pathogenetic and clinical relevance of …

Polysaccharides can be elite carriers for therapeutic molecules due to their versatility and
low probability to trigger toxicity and immunogenic responses. Local and systemic therapies …

Following acute injury, the capillary vascular bed in the lung must be repaired to reestablish
gas exchange with the external environment. Little is known about the transcriptional and …

Over the past years, advanced in vitro pulmonary platforms have witnessed exciting
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …

The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

Vascularization plays a crucial role in transporting and exchanging nutrients and oxygen
between implanted grafts with the host tissue. In the biofabrication of the implanted grafts …

Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function
via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the …