Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …

Chronic myeloid leukemia (CML) is one of the most common leukemias occurring in the
adult population. The course of CML is divided into three phases: the chronic phase, the …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
(Ph) which results from a reciprocal translocation between chromosomes 9 and 22 [t (9; 22] …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
(Ph), resulting from a reciprocal translocation between chromosomes 9 and 22 [t (9; 22] that …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
resulting from a reciprocal translocation between chromosomes 9 and 22 [t9; 22] that gives …

Several papers authored by international experts have proposed recommendations on the
management of BCR-ABL1+ chronic myeloid leukemia (CML). Following these …

The constitutively active BCR-ABL1 tyrosine kinase, found in t (9; 22)(q34; q11)
chromosomal translocation-derived leukemia, initiates an extremely complex signaling …

Chronic myeloid leukemia (CML) is a type of blood cancer that is known to affect
hematopoietic stem cells. The presence of the Philadelphia chromosome (Ph+) is the major …

At diagnosis of chronic-phase chronic myeloid leukemia (CML), there are conflicting data as
to whether additional cytogenetic abnormalities (ACAs) beyond a standard Philadelphia …

In 2020, for the great majority of patients with chronic phase chronic myeloid leukemia
(CML), life expectancy is unaffected by a diagnosis of CML because of the unparalleled …